Pub. Date : 2002 Nov
PMID : 12569976
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: The effect of arachidonic acid or platelet agonists on LTC4 synthase activity was investigated in platelets obtained from healthy volunteers, aspirin-intolerant asthmatics or aspirin-tolerant asthmatics after in vivo treatment or in vitro pre-incubation with aspirin. | Arachidonic Acid | leukotriene C4 synthase | Homo sapiens |
| 2 | RESULTS: Incubation of normal platelets with arachidonic acid or collagen provoked approximately 50% reduction of platelet LTC4 synthase activity, as determined by the conversion of LTA4 to LTC4. | Arachidonic Acid | leukotriene C4 synthase | Homo sapiens |
| 3 | Arachidonic acid-induced inhibition of LTC4 synthase activity was totally abolished in platelets collected from peripheral blood already 30 min after aspirin ingestion but was fully restored in platelets collected 3 to 7 days after the administration of aspirin. | Arachidonic Acid | leukotriene C4 synthase | Homo sapiens |
| 4 | Similarly, LTC4 synthase activity in platelets from AIA and aspirin-tolerant asthmatics (ATA) was reduced by approximately 50% after pre-treatment with arachidonic acid in vitro. | Arachidonic Acid | leukotriene C4 synthase | Homo sapiens |