Title : Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.

Pub. Date : 2003 Feb 10

PMID : 12569393






1 Functional Relationships(s)
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1 2-(4-Amino-3-methylphenyl)benzothiazole-derived covalent binding to cytochrome P450 1A1 is reduced by glutathione, suggesting 1A1-dependent production of a reactive electrophilic species. Glutathione cytochrome P450 family 1 subfamily A member 1 Homo sapiens