Title : Argatroban, specific thrombin inhibitor, induced phenotype change of cultured rabbit vascular smooth muscle cells.

Pub. Date : 2003 Feb 7

PMID : 12568910






3 Functional Relationships(s)
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1 Other phenotype markers including plasminogen activator inhibitor-1 (PAI-1) and beta-actin mRNAs were also significantly increased by argatroban. argatroban plasminogen activator inhibitor 1 Oryctolagus cuniculus
2 Other phenotype markers including plasminogen activator inhibitor-1 (PAI-1) and beta-actin mRNAs were also significantly increased by argatroban. argatroban plasminogen activator inhibitor 1 Oryctolagus cuniculus
3 In conclusion, argatroban can directly induce phenotype conversion of vascular smooth muscle cells with the resultant up-regulation of SMemb, PAI-1, and beta-actin mRNAs. argatroban plasminogen activator inhibitor 1 Oryctolagus cuniculus