Title : Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.

Pub. Date : 2003 Apr 25

PMID : 12566446






1 Functional Relationships(s)
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1 In this report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible with aryl hydrocarbon receptor (Ah receptor) ligands such as 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD), beta-naphthoflavone, and benzo[a]pyrene metabolites. Benzo(a)pyrene UDP glucuronosyltransferase family 1 member A1 Homo sapiens