Title : Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.

Pub. Date : 2003 Feb 1

PMID : 12566303






2 Functional Relationships(s)
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Protein Name
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1 With MPG overexpression, an increase in DNA damage and increased cytotoxicity to methyl methanesulfonate as well as increased apoptosis levels was observed in these cells. Methyl Methanesulfonate N-methylpurine DNA glycosylase Homo sapiens
2 Overexpression of the mitochondrially targeted MPG dramatically increased the breast cancer cells" sensitivity to methyl methanesulfonate. Methyl Methanesulfonate N-methylpurine DNA glycosylase Homo sapiens