Title : Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent.

Pub. Date : 2003 Feb 15

PMID : 12566077






1 Functional Relationships(s)
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1 In comparison, Bcl-2 overexpression drastically reduced apoptotic DNA fragmentation by etoposide, acting via topoisomerase II-mediated DNA damage, but had no effect on apoptotic DNA fragmentation by helenalin A, which reacts with proteins but not DNA. Etoposide BCL2 apoptosis regulator Homo sapiens