Title : Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

Pub. Date : 2003 Feb

PMID : 12563018






1 Functional Relationships(s)
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1 Stepwise assembly experiments have shown that hsp70 and hsp40 first interact with the receptor in an ATP-dependent reaction to produce a receptor*hsp70*hsp40 complex that is "primed" to be activated to the steroid-binding state in a second ATP-dependent step with hsp90, Hop, and p23. Steroids heat shock protein 90 alpha family class A member 1 Homo sapiens