Pub. Date : 2002 Dec
PMID : 12562045
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As a result of these biochemical effects on the mevalonate pathway, bisphosphonates appear to modulate the expression of bcl-2 leading to caspase-dependent apoptosis, inhibit matrix metalloproteinases, downregulate alphavbeta3 and alphavbeta5 integrins, and increase expression of osteoprotegerin, thereby antagonizing osteoclastogenesis. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |