Title : Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.

Pub. Date : 2003 Jan 30

PMID : 12555062






2 Functional Relationships(s)
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Protein Name
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1 Paclitaxel-induced p70S6K(T421/S424) phosphorylation requires both de novo RNA and protein synthesis via multiple signaling pathways including ERK1/2 MAP kinase, JNK, PKC, Ca(++), PI3K, and mammalian target of rapamycin (mTOR). Paclitaxel mitogen-activated protein kinase 8 Homo sapiens
2 Inhibition of PKC and JNK prevents paclitaxel-induced p70S6K inactivation. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens