Title : Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

Pub. Date : 2003 May

PMID : 12554767






1 Functional Relationships(s)
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1 Akt activation was blocked by wortmannin and LY 294,002, two inhibitors of PI 3-K; by genistein, a protein tyrosine kinase inhibitor and an ER agonist; by AG825, a selective ErbB2 inhibitor; and by the antiestrogens ICI 182,780 and 4-hydroxy-tamoxifen; but not by rapamycin, an inhibitor of the ribosomal protein kinase p70S6K; nor by AG30, a selective epidermal growth factor receptor inhibitor. 4'-hydroxytamoxifen AKT serine/threonine kinase 1 Homo sapiens