Title : Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.

Pub. Date : 2003 May 9

PMID : 12551920






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We found that BACE undergoes cleavage on a surface-exposed alpha-helix between amino acid residues Leu-228 and Ala-229, generating stable N- and C-terminal fragments that remain covalently associated via a disulfide bond. Leucine beta-secretase 1 Homo sapiens