Pub. Date : 2003 Apr 11
PMID : 12547826
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. | arsenite | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | We have shown previously that arsenite can potently activate the mitogen-activated protein kinase cascades and induce the expression of proliferation-associated genes, including proto-oncogenes c-jun and c-fos. | arsenite | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | In order to elucidate further the molecular mechanisms underlying its tumor-promoting properties, we investigated the signaling events involved in arsenite-mediated induction of c-fos and c-jun. | arsenite | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation. | arsenite | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | Interestingly, arsenite dramatically induced the phosphorylation and acetylation of histone H3 preceding the induction of mRNAs encoding c-fos and c-jun. | arsenite | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway. | arsenite | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |