Title : Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment.

Pub. Date : 2003 Feb 1

PMID : 12543247






2 Functional Relationships(s)
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1 We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of glutathione peroxidase (GPx), and 3-amino-1,2,4-triazole (AT), a direct inhibitor of catalase (CAT), should cause toxicity to cancer cells after manganese superoxide dismutase (MnSOD) overexpression due to elevated peroxide levels. Peroxides superoxide dismutase 2 Homo sapiens
2 We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of glutathione peroxidase (GPx), and 3-amino-1,2,4-triazole (AT), a direct inhibitor of catalase (CAT), should cause toxicity to cancer cells after manganese superoxide dismutase (MnSOD) overexpression due to elevated peroxide levels. Peroxides superoxide dismutase 2 Homo sapiens