Title : YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase.

Pub. Date : 2003 Mar 28

PMID : 12540839






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase. Histidine RNA binding motif single stranded interacting protein 1 Homo sapiens
2 These results revealed that YC-1 facilitated cleavage of the proximal His-iron bond and caused geometrical distortion of the five-coordinate NO-heme. Histidine RNA binding motif single stranded interacting protein 1 Homo sapiens
3 These results indicate that YC-1 stimulates enzyme activity by weakening or cleaving the proximal His-iron bond in the CO complex as well as the NO complex. Histidine RNA binding motif single stranded interacting protein 1 Homo sapiens