Title : PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.

Pub. Date : 2003 Feb

PMID : 12529250






2 Functional Relationships(s)
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1 We tested the hypothesis that platelet-derived growth factor (PDGF)-mediated PASMC growth involves upregulation of c-Jun and TRPC6, a transient receptor potential cation channel. pasmc Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 These results suggest that PDGF-mediated PASMC proliferation is associated with c-Jun/STAT3-induced upregulation of TRPC6 expression. pasmc Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens