Pub. Date : 2003 Jan 16
PMID : 12527890
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 2 | It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 3 | It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 4 | It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 5 | It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 6 | Currently, little is known about whether EGFR or its tyrosine kinase is necessary for TPA-induced AP-1 activation. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 7 | We demonstrated that the TPA or epidermal growth factor (EGF) induced AP-1 activation in the B82L cells that express wild-type EGFR, but not in the B82 cell, whereas autophosphorylation at tyrosine(1173) of EGFR in B82L cells was only induced by EGF, but not TPA. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 8 | The expression of tyrosine kinase-deficient EGFR (mutation at Lys-721) (B82M721) resulted in deficiency of AP-1 induction in cellular response to EGF, while TPA treatment led to fully AP-1 activation. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 9 | Based on these results, we conclude that TPA-induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |
| 10 | Based on these results, we conclude that TPA-induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation. | Tetradecanoylphorbol Acetate | jun proto-oncogene | Mus musculus |