Title : Improved myocardial function using a Na+/H+ exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass.

Pub. Date : 2003 Jan

PMID : 12527621






3 Functional Relationships(s)
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1 Myocardial ischemia/reperfusion that occurs with CPB/CPA activates the Na(+)/H(+) exchanger to normalize intracellular pH, with intracellular Na(+) (and water) accumulation. cpa solute carrier family 9 member A1 Canis lupus familiaris
2 We hypothesized that Na(+)/H(+) exchanger inhibition with a selective inhibitor (EMD 87580) would decrease myocardial edema and improve myocardial performance after CPB/CPA. cpa solute carrier family 9 member A1 Canis lupus familiaris
3 CONCLUSION: Na(+)/H(+) exchanger inhibition improves systolic but not diastolic function after CPB/CPA. cpa solute carrier family 9 member A1 Canis lupus familiaris