Title : Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes.

Pub. Date : 2002 Nov 30

PMID : 12526099






4 Functional Relationships(s)
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1 Treatment of cells with TNF in the presence of all-trans-retinoic acid (RA) significantly decreased their ability to produce nitrite and iNOS induction. Tretinoin tumor necrosis factor Homo sapiens
2 Treatment of cells with TNF in the presence of all-trans-retinoic acid (RA) significantly decreased their ability to produce nitrite and iNOS induction. Tretinoin tumor necrosis factor Homo sapiens
3 The inhibitory effect of RA on TNF-induced iNOS induction was reversible, completely recovered after 2 days, and was exerted through the inhibition of NF-kappaB activation. Tretinoin tumor necrosis factor Homo sapiens
4 RA could not reverse the TNF- induced LPL suppression at RA levels causing near complete inhibition of the TNF-induced NO production. Tretinoin tumor necrosis factor Homo sapiens