Pub. Date : 2003 Mar 21
PMID : 12525500
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. | pregna-4,17-diene-3,16-dione | ATP binding cassette subfamily B member 11 | Homo sapiens |
| 2 | Taken together, these data suggest that guggulsterone defines a novel class of FXR ligands characterized by antagonist activities in coactivator association assays but with the ability to enhance the action of agonists on BSEP expression in vivo. | pregna-4,17-diene-3,16-dione | ATP binding cassette subfamily B member 11 | Homo sapiens |