Title : p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling.

Pub. Date : 2003 Mar 14

PMID : 12522133






2 Functional Relationships(s)
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1 A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR. Proline growth factor receptor bound protein 2 Homo sapiens
2 A cell-permeant TAT-tagged peptide encompassing the second proline-rich SH3 binding domain of PAK1 simultaneously blocked Grb2 and activated EGFR association with PAK1, in vitro and in vivo, indicating that Grb2 mediates the interaction of PAK1 with the activated EGFR. Proline growth factor receptor bound protein 2 Homo sapiens