Title : Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding.

Pub. Date : 2003 Mar 21

PMID : 12519787






1 Functional Relationships(s)
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1 Using real-time quantitative PCR and cotransfection reporter assays, we demonstrate that the RXR agonist LG100268 antagonizes induction of BSEP expression mediated by endogenous and synthetic FXR ligands, CDCA and GW4064, respectively. GW 4064 ATP binding cassette subfamily B member 11 Homo sapiens