Pub. Date : 2003 Feb
PMID : 12510010
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intravenous injection of the cholecystokinin (CCK)-B receptor agonist, pentagastrin, produces robust, dose-dependent release of adrenocorticotropin (ACTH) and cortisol, supporting the hypothesis that CCK-B agonists pharmacologically activate the hypothalamic-pituitary-adrenal (HPA) axis. | Pentagastrin | proopiomelanocortin | Homo sapiens |
| 2 | Preliminary data suggest that the ACTH response to pentagastrin may be differentiated from the response to exogenous corticotropin releasing hormone (CRH) by its relative resistance to cortisol feedback inhibition. | Pentagastrin | proopiomelanocortin | Homo sapiens |
| 3 | ACTH responses to pentagastrin were identical in the morning and afternoon, despite substantial differences in basal cortisol levels. | Pentagastrin | proopiomelanocortin | Homo sapiens |