Pub. Date : 2002 Dec
PMID : 12507920
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this review, we summarize the published data on modulation of (+)-anti-BPDE-DNA adduct levels in smokers" lungs by CYP1A1*2 genotypes alone or in combination with GSTM1 polymorphism and compare these results with those reported for aromatic/hydrophobic (bulky) DNA adducts. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |