Title : CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation.

Pub. Date : 2002 Dec

PMID : 12507920






1 Functional Relationships(s)
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1 These results are also consistent with the hypothesis that BP (PAH) induce G:C to T:A transversion mutations in the hotspot codons of the p53 tumor suppressor gene and are thus involved in malignant transformation of the lung tissue of smokers. Benzo(a)pyrene tumor protein p53 Homo sapiens