Title : Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide.

Pub. Date : 2003 Jan

PMID : 12507730






1 Functional Relationships(s)
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1 The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors, by preventing the compromise of the enzyme activity, can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients. Vitamin E acetylcholinesterase (Cartwright blood group) Homo sapiens