Title : Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.

Pub. Date : 2002 Dec 27

PMID : 12505323






1 Functional Relationships(s)
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1 In summary, we have found that protection by GSTs against B[a]P or DiB[a,l]P toxicity is highly variable depending on differences in: (a) the PAH structure; (b) the human vs. rat CYP1A1 expressed; (c) GST isozyme(s) expressed; (d) cellular expression of conjugate transporters; or (e) DNA damage versus cytoxicity end-points. p-Aminohippuric Acid glutathione S-transferase mu 1 Homo sapiens