Pub. Date : 2002 Dec 27
PMID : 12505310
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | With the exception of pravastatin, the remaining 15 compounds transactivated the CYP3A4 reporter gene with differing inductive abilities (I(max):EC(50)) over two orders of magnitude, ranging from 1.1 (phenytoin) to 222.9 (lovastatin) in a receptor-supplemented system and it is proposed that the lack of response to pravastatin is due to loss of the known hepatic uptake transporter in HepG2 cells. | Lovastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |