Pub. Date : 2002 Dec
PMID : 12504922
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | This study tested if sodium valproate or lithium, two agents used to treat bipolar mood disorder, altered the regulatory phosphorylations of Akt or glycogen synthase kinase-3beta (GSK3beta) in human neuroblastoma SH-SY5Y cells. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | This study tested if sodium valproate or lithium, two agents used to treat bipolar mood disorder, altered the regulatory phosphorylations of Akt or glycogen synthase kinase-3beta (GSK3beta) in human neuroblastoma SH-SY5Y cells. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |
| 4 | Treatment with sodium valproate caused a gradual but relatively large increase in the activation-associated phosphorylation of Akt on Ser-473, and a similarly gradual but more modest increase in the inhibition-associated phosphorylation of GSK3beta on Ser-9. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |
| 5 | Two other inhibitors of histone deacetylase, a recently identified target of sodium valproate, also caused gradual increases in the phosphorylation of Akt and GSK3beta. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |
| 6 | These results identify novel effects of sodium valproate on the Akt/GSK3beta signaling pathway, indicating that histone deacetylase inhibition is linked to activation of Akt, and show that two anti-bipolar agents have a common action, the increased inhibitory phosphorylation of Ser-9-GSK3beta. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |
| 7 | These results identify novel effects of sodium valproate on the Akt/GSK3beta signaling pathway, indicating that histone deacetylase inhibition is linked to activation of Akt, and show that two anti-bipolar agents have a common action, the increased inhibitory phosphorylation of Ser-9-GSK3beta. | Valproic Acid | glycogen synthase kinase 3 beta | Homo sapiens |