Title : Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase.

Pub. Date : 2003 Feb 28

PMID : 12493777






2 Functional Relationships(s)
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1 All of these residues proved to be crucial also for NDR1 activity in vivo; however, in contrast to Ser-281 and Thr-444, Thr-74 seems to be involved only in binding to S100B rather than directly regulating NDR1 activity per se. Threonine S100 calcium binding protein B Homo sapiens
2 When we added Ca(2+)/S100B, we observed an increased autophosphorylation on Ser-281 and Thr-444, resulting in stimulation of NDR1 activity in vitro. Threonine S100 calcium binding protein B Homo sapiens