Title : Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.

Pub. Date : 2003 Feb 28

PMID : 12493764






3 Functional Relationships(s)
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1 Thrombin stimulation of the VCAM-1 gene and promoter in human umbilical vein endothelial cells was inhibited by preincubation with the phosphatidylinositol 3-kinase inhibitor, LY294002, the protein kinase C (PKC)-delta inhibitor, rottlerin, a PKC-zeta peptide inhibitor, or by overexpression of dominant negative (DN)-PKC-zeta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one vascular cell adhesion molecule 1 Homo sapiens
2 In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one vascular cell adhesion molecule 1 Homo sapiens
3 In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one vascular cell adhesion molecule 1 Homo sapiens