Pub. Date : 2003 Jan
PMID : 12492458
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected]. | Atorvastatin | interleukin 10 | Homo sapiens |
| 2 | RESULTS: Treatment of the subjects with atorvastatin decreased the abundance of IL-12p35 mRNA in mononuclear cells, but did not alter that of IL-10, so that the ratio of the IL-12p35 to IL-10 mRNA content was significantly reduced (P < 0.0026). | Atorvastatin | interleukin 10 | Homo sapiens |
| 3 | CONCLUSIONS: This study provides evidence that atorvastatin exerts an immunomodulatory effect in vivo, characterized by a decrease in the ratio of IL-12 mRNA to IL-10 mRNA in leukocytes. | Atorvastatin | interleukin 10 | Homo sapiens |