Pub. Date : 2002 Dec 15
PMID : 12490779
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: The dose-normalized blood concentrations of tacrolimus at 3 months after renal transplantation were related to CYP3AP1 and multiple drug resistance (MDR)-1 genotypes determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis. | Tacrolimus | cytochrome P450 family 3 subfamily A member 51, pseudogene | Homo sapiens |
| 2 | RESULTS: We found that a single nucleotide polymorphism in the CYP3AP1 pseudogene (A/G(44)) that previously has been noted to be more common in African Americans and strongly associated with hepatic CYP3A5 activity correlated well with the tacrolimus dose requirement. | Tacrolimus | cytochrome P450 family 3 subfamily A member 51, pseudogene | Homo sapiens |
| 3 | CONCLUSIONS: The CYP3AP1 genotype is a major factor in determining the dose requirement for tacrolimus, and genotyping may be of value in planning patient-specific drug dosing. | Tacrolimus | cytochrome P450 family 3 subfamily A member 51, pseudogene | Homo sapiens |