Pub. Date : 2002 Nov
PMID : 12489993
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, we have demonstrated that increased superoxide generation plays a role in the nitric oxide (NO)-mediated inhibition of endothelial NO synthase (NOS III) in endothelial cells (ECs). | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 2 | In this study we demonstrate that the source of the superoxide is likely due to both NADPH oxidase and NOS III itself. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 3 | In conclusion, our results indicate that superoxide and peroxynitrite are involved in the inhibition of NOS III by NO, and that the scavenging of superoxide may be necessary to prevent NOS III inhibition during treatments that involve inhaled NO or NO donors. | Superoxides | nitric oxide synthase 3 | Homo sapiens |