Title : Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells.

Pub. Date : 2002 Nov

PMID : 12487732






3 Functional Relationships(s)
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1 By screening the ingredients in the medium, the serum had no effect on CYP1A1 induction, whereas both photo-oxidized and autoclaved tryptophan were shown to induce CYP1A1, as indicated by CYP1A1 protein or ethoxyresorufin-O-deethylase activity. Tryptophan cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 By screening the ingredients in the medium, the serum had no effect on CYP1A1 induction, whereas both photo-oxidized and autoclaved tryptophan were shown to induce CYP1A1, as indicated by CYP1A1 protein or ethoxyresorufin-O-deethylase activity. Tryptophan cytochrome P450 family 1 subfamily A member 1 Homo sapiens
3 The autoclaved tryptophan contained in an autoclavable medium was a more potent inducer of CYP1A1 than photo-oxidized tryptophan. Tryptophan cytochrome P450 family 1 subfamily A member 1 Homo sapiens