Title : The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex.

Pub. Date : 2003 Feb 21

PMID : 12482880






2 Functional Relationships(s)
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Protein Name
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1 Upon engagement with Fas ligand (FasL), Fas rapidly induces recruitment and self-processing of caspase-8 via the adaptor protein Fas-associated death domain (FADD), and activated caspase-8 cleaves downstream substrates such as caspase-3. ammonium ferrous sulfate caspase 8 Homo sapiens
2 Upon engagement with Fas ligand (FasL), Fas rapidly induces recruitment and self-processing of caspase-8 via the adaptor protein Fas-associated death domain (FADD), and activated caspase-8 cleaves downstream substrates such as caspase-3. ammonium ferrous sulfate caspase 8 Homo sapiens