Pub. Date : 2003 Jan
PMID : 12482638
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels. | Glucose | angiotensinogen | Homo sapiens |
| 2 | This study investigates the mechanisms for glucose-induced increase in angiotensin II (AII) production by human mesangial cells (MCs) in relation to protein kinase C (PKC). | Glucose | angiotensinogen | Homo sapiens |
| 3 | This study investigates the mechanisms for glucose-induced increase in angiotensin II (AII) production by human mesangial cells (MCs) in relation to protein kinase C (PKC). | Glucose | angiotensinogen | Homo sapiens |
| 4 | We also examine whether locally produced AII mediates extracellular matrix protein production in high-glucose conditions. | Glucose | angiotensinogen | Homo sapiens |
| 5 | The amount of AII secreted from MCs exposed to high-glucose levels was significantly greater (P<0.01) than that in normal glucose levels. | Glucose | angiotensinogen | Homo sapiens |
| 6 | The amount of AII secreted from MCs exposed to high-glucose levels was significantly greater (P<0.01) than that in normal glucose levels. | Glucose | angiotensinogen | Homo sapiens |
| 7 | The addition of PDBu mimicked the effect of glucose on AII production. | Glucose | angiotensinogen | Homo sapiens |
| 8 | These results suggest that elevated glucose levels stimulate AII production via mechanisms dependent on glucose-induced PKC activation in human MCs, and that locally produced AII partly mediates the increase in mesangial matrix synthesis in high-glucose conditions. | Glucose | angiotensinogen | Homo sapiens |