Title : Interleukin-6 and mast cells.

Pub. Date : 2002 Sep-Oct

PMID : 12476543






2 Functional Relationships(s)
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1 Human cord blood CD34+ cells differentiate and grow into mast cells in the presence of stem cell factor (SCF) and IL-6, causing increases in cell size, frequency of chymase positive cells, and intracellular histamine levels when compared with cells treated with SCF alone. Histamine interleukin 6 Homo sapiens
2 IL-6 also up-regulates histamine production rather than increases its storage and is an important inducing factor for the expression of immunoglobulin E (IgE) Fc epsilon RI. Histamine interleukin 6 Homo sapiens