Pub. Date : 2002 Dec
PMID : 12476424
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene. | Heroin | catechol-O-methyltransferase | Homo sapiens |
| 2 | OBJECTIVE: To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene. | Heroin | catechol-O-methyltransferase | Homo sapiens |
| 3 | METHODS: Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls. | Heroin | catechol-O-methyltransferase | Homo sapiens |
| 4 | RESULTS: Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. | Heroin | catechol-O-methyltransferase | Homo sapiens |
| 5 | The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017). | Heroin | catechol-O-methyltransferase | Homo sapiens |