Title : The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".

Pub. Date : 2003 Feb 14

PMID : 12475976






1 Functional Relationships(s)
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1 These results reveal the existence of a novel mechanism of Rac activation by a guanine nucleotide exchange factor and suggest that the induction by Trio of a conformational change in Rac1, in the absence of nucleotide exchange, is sufficient for enhancing its effector function. Guanine Nucleotides AKT serine/threonine kinase 1 Homo sapiens