Pub. Date : 2003 Jan 20
PMID : 12471621
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | MCP-1 antigen levels increased approximately 100-fold in doxorubicin-treated H69 cells. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |
| 6 | IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |
| 7 | IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology. | Doxorubicin | C-C motif chemokine ligand 2 | Homo sapiens |