Title : The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans.

Pub. Date : 2002 Dec

PMID : 12466036






1 Functional Relationships(s)
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1 Pro-inflammatory cytokines such as IL-1beta, IFN-alpha, IFN-gamma and TNF-alpha affect the 5-HT metabolism directly and/or indirectly by stimulating the enzyme indoleamine 2,3-dioxygenase which leads to a peripheral depletion of tryptophan. Tryptophan interleukin 1 beta Homo sapiens