Pub. Date : 2002 Dec
PMID : 12463723
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone: effect on CYP3A4 activity. | Pioglitazone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Clinical studies demonstrate CYP3A4 enzyme induction with troglitazone, a thiazolidinedione derivative structurally related to pioglitazone. | Pioglitazone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The objective of this prospective, open-label study conducted in healthy volunteers was to evaluate the influence of multiple-dose pioglitazone therapy on the urinary excretion ratio of 6-beta-hydroxycortisol to cortisol, an endogenous marker of CYP3A4 activity. | Pioglitazone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |