Title : Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.

Pub. Date : 2002 Dec

PMID : 12454742






1 Functional Relationships(s)
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1 Collectively, the results demonstrate that expression of E45K hRFC leads to increased MTX resistance due to decreased membrane transport and, secondarily, from alterations in binding affinities and transport of folate substrates. Folic Acid solute carrier family 19 member 1 Homo sapiens