Title : Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease.

Pub. Date : 2002 Dec

PMID : 12454562






3 Functional Relationships(s)
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1 Donepezil and rivastigmine are acetylcholinesterase (AChE) inhibitors used to improve cholinergic neurotransmission and cognitive function in Alzheimer"s disease (AD). Rivastigmine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The present study provides first evidence for the effect of rivastigmine on cortical AChE activity. Rivastigmine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Our results indicate that the pooled effects of donepezil and rivastigmine on brain AChE are greater in the frontal cortex compared to the temporal cortex in AD. Rivastigmine acetylcholinesterase (Cartwright blood group) Homo sapiens