Pub. Date : 2002 Dec
PMID : 12454562
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Donepezil and rivastigmine are acetylcholinesterase (AChE) inhibitors used to improve cholinergic neurotransmission and cognitive function in Alzheimer"s disease (AD). | Donepezil | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Treatment with donepezil reduced the AChE activity (k3 values) in the AD brain by 39% in the frontal (p < 0.001, Bonferroni corrected), 29% in the temporal (p = 0.02, corrected) and 28% in the parietal cortex (p = 0.05, corrected). | Donepezil | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Our results indicate that the pooled effects of donepezil and rivastigmine on brain AChE are greater in the frontal cortex compared to the temporal cortex in AD. | Donepezil | acetylcholinesterase (Cartwright blood group) | Homo sapiens |