Pub. Date : 2002 Dec 20
PMID : 12447997
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pre-treatment of the PC-3 cells with LPA decreases the dose of EGF required to elicit maximal activation of EGFR. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 2 | Furthermore, treatment with LPA alone induces the rapid (maximal signal within 2 min) tyrosine phosphorylation of EGFR, and subsequent (maximal signal after 5 min) activation of ERK, suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 3 | Furthermore, treatment with LPA alone induces the rapid (maximal signal within 2 min) tyrosine phosphorylation of EGFR, and subsequent (maximal signal after 5 min) activation of ERK, suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 4 | Accordingly, we show that inhibition of EGFR kinase activity attenuates the LPA-regulated ERK activation. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 5 | In addition, we find that the LPA-regulated tyrosine phosphorylation of EGFR and activation of ERK are attenuated by batimastat, a generic inhibitor of matrix metalloproteinases (MMP). | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 6 | However, unlike the situation in fibroblasts, we find that the LPA-induced transactivation of EGFR in PC-3 cells is not mediated by shedding of heparin-binding EGF. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |