Title : Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase.

Pub. Date : 2002 Dec 15

PMID : 12445859






2 Functional Relationships(s)
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1 The current study was designed to examine the NO dependencies of the down-regulation of phenobarbital-induced CYP2B mRNAs and proteins by bacterial endotoxin (lipopolysaccharide, LPS) treatment in vivo, using an NOS2-null mouse model. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus
2 Treatment of C57/BL6 mice with 0.3 mg/kg of LPS maximally suppressed phenobarbital-induced CYP2B9 and 2B10 mRNAs measured 12 hr after injection, whereas 1-10 mg/kg of LPS was required to elevate NO production. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus