Pub. Date : 2002 Nov
PMID : 12444898
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Various clinical and experimental findings support the concept that human chorionic gonadotropin (hCG) can stimulate iodide uptake in thyroid cells. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 2 | DESIGN: We investigated the molecular mechanisms underlying the effects of hCG on iodide uptake, and particularly its action on the expression of Na+/I- symporter (NIS) mRNA and protein. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 3 | RESULTS: Iodide uptake was increased by hCG in a dose- and time-dependent manner: maximal effects were observed after 72 h of stimulation. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 4 | CONCLUSION: Our data demonstrated that hCG stimulates iodide uptake in FRTL-5 cells by increasing NIS mRNA and protein levels. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |