Title : Retinoid-induced apoptosis in B-cell chronic lymphocytic leukaemia cells is mediated through caspase-3 activation and is independent of p53, the retinoic acid receptor, and differentiation.

Pub. Date : 2002 Oct

PMID : 12431242






1 Functional Relationships(s)
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1 ATRA induced apoptosis in all the B-CLL samples tested, and this was accompanied by a specific reduction in Bcl-2 and Mcl-1 protein expression in the apoptotic cells. Tretinoin MCL1 apoptosis regulator, BCL2 family member Homo sapiens