Pub. Date : 2002 Nov 15
PMID : 12426371
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NMR analysis shows that the Fyn but not the Lck tyrosine kinase SH3 domain competes with CD2BP2 GYF-domain binding to the same CD2 proline-rich sequence in vitro. | Proline | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 2 | To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering. | Proline | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |